Redefining pathogenicity and vaccine research.
Gain mechanistic insights and pathophysiological responses
Detailed knowledge of the events and mechanisms that enable a pathogen to infect a cell can open new avenues for biomedical defense. How cells respond to infections can manifest as, for example, genomic integrations of viral sequences, altered protein expression, and secretion profiles of host cells, as well as a restructuring of surface signals.
Tracking these manifestations, as well as understanding how cells interact with pathogens and immune cells, is central to expanding our arsenal against infectious disease – be it through fast and precise diagnostics, preventative vaccines, effective antibiotics or antivirals, and therapeutic suppression of auto immune stimulation and cytokine storm.
from CellCity in regards to infectious diseases:
Link infection mechanism and host cell phenotype at single-cell resolution
Elucidate changes in surface protein expression resulting from infection (e.g., MCP-1, VCAM-1, ICAM-1, neoantigens)
Examine infection pathways used by bacteria and viruses
Document altered mRNA profiles due to infection (e.g., NS1, viral mRNA)
Visualize host cell interactions with monocytes, macrophages, T lymphocytes, and other immune cells
Describe cellular secretions triggered by infection (e.g., TNF-a, INF-g, IL-6)